Drugs that affect or may affect qt interval

Biggest problem is the proven drugs to cause torsades (drugs we see a lot)

Citalopram Celexa® Anti-depressant / depression

Erythromycin E.E.S.® Antibiotic;GI stimulant / bacterial infection; increase GI motility

Haloperidol Haldol® Anti-psychotic / schizophrenia, agitation When given intravenously or at higher-than- recommended doses, 
Methadone Dolophine® Opiate agonist / pain control, narcotic dependence

Quinidine Nuedexta® for PBA

 

The possible list to cause torsades, which is in my mind, the same risk as those above (drugs we use a lot):

Amantadine Symmetrel® Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease

Dolasetron Anzemet® Anti-nausea / nausea, vomiting

Escitalopram Lexapro® Anti-depressant / Major depression/ Anxiety disorders

Famotidine Pepcid® H2-receptor antagonist / Peptic ulcer/ GERD

Fosphenytoin Cerebyx® Anti-convulsant / seizure

Granisetron Kytril® Anti-nausea

Levofloxacin Levaquin® Antibiotic / bacterial infection

Quetiapine Seroquel® Anti-psychotic / schizophrenia

Risperidone Risperdal® Anti-psychotic / schizophrenia
Tizanidine Zanaflex® Muscle relaxant

Venlafaxine Effexor® Anti-depressant / depression

Ziprasidone Geodon® Anti-psychotic / schizophrenia

 

The conditional ones (which we see used sometimes) which given the right circumstances (OD, drug interactions) cause torsades

All tricyclics (amitriptyline, doxepin, despipramine, imipramine, nortriptyline, trazodone among others).

Cyclobenzaprine is a tricyclic.

All other SSRI paroxetine, fluoxetine (not enough data on duloxetine milnacipran)

All fluoroquinolone antibiotics and TMP SMX

And azole antifungal agents

 

So ALL antidepressants, ALL antipsychotics, most muscle relaxants, most antibiotics. Don't forget Pepcid! As well as beta blockers, clonidine, calcium channel blockers (verapamil, diltaizem and a few others), quinine, quinidine, amiodarone.

 

THE GOOD NEWS IS THAT XANAX ISN'T ON THE LIST – I THINK I NEED SOME.

 

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