Tuesday, May 15, 2012

Drugs that affect or may affect qt interval

Biggest problem is the proven drugs to cause torsades (drugs we see a lot)
Citalopram Celexa® Anti-depressant / depression
Erythromycin E.E.S.® Antibiotic;GI stimulant / bacterial infection; increase GI motility
Haloperidol Haldol® Anti-psychotic / schizophrenia, agitation When given intravenously or at higher-than- recommended doses, 
Methadone Dolophine® Opiate agonist / pain control, narcotic dependence
Quinidine Nuedexta® for PBA
 
The possible list to cause torsades, which is in my mind, the same risk as those above (drugs we use a lot):
Amantadine Symmetrel® Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease
Dolasetron Anzemet® Anti-nausea / nausea, vomiting
Escitalopram Lexapro® Anti-depressant / Major depression/ Anxiety disorders
Famotidine Pepcid® H2-receptor antagonist / Peptic ulcer/ GERD
Fosphenytoin Cerebyx® Anti-convulsant / seizure
Granisetron Kytril® Anti-nausea
Levofloxacin Levaquin® Antibiotic / bacterial infection
Quetiapine Seroquel® Anti-psychotic / schizophrenia
Risperidone Risperdal® Anti-psychotic / schizophrenia
Tizanidine Zanaflex® Muscle relaxant
Venlafaxine Effexor® Anti-depressant / depression
Ziprasidone Geodon® Anti-psychotic / schizophrenia
 
The conditional ones (which we see used sometimes) which given the right circumstances (OD, drug interactions) cause torsades
All tricyclics (amitriptyline, doxepin, despipramine, imipramine, nortriptyline, trazodone among others).
Cyclobenzaprine is a tricyclic.
All other SSRI paroxetine, fluoxetine (not enough data on duloxetine milnacipran)
All fluoroquinolone antibiotics and TMP SMX
And azole antifungal agents
 
So ALL antidepressants, ALL antipsychotics, most muscle relaxants, most antibiotics. Don't forget Pepcid! As well as beta blockers, clonidine, calcium channel blockers (verapamil, diltaizem and a few others), quinine, quinidine, amiodarone.
 
THE GOOD NEWS IS THAT XANAX ISN'T ON THE LIST – I THINK I NEED SOME.
 
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