Multiple Sclerosis Notes

Buron MD, Chalmer TA, Sellbjerg F.  Initial high-efficacy disease-modifying therapy in multiple sclerosis. A nationwide cohort study. Neurol...

prednisone 50 mg Number 125 tablets Each day for five days, crush 25  tablets into powder, mix with orange soda take orally  

https://www.summitmedicalgroup.com/library/adult_health/sma_piriformis_syndrome_exercises/

Ponesimod won decisively in this phase 2 study in RRMS. 1333 patients were randomized. Ponesimod group had lower ARR,  by 30 percent;  less...

Barkhof F, Kappos L, Wolinsky J.  Neurology; 2019; e1778-1786. Authors analyzed 163 individuals from partly blinded  phase II trials of o...

https://www.ema.europa.eu/en/medicines

https://www.bicams.net/

Heat management 1.  cool pool 2,  Avoid hot showers 3. Hydration 4.  cooling vests and packs 5.  Lightweight clothes 6.  Rest a...

http://www.nationalmssociety.org/For-Professionals/Researchers/Resources-for-Researchers/Clinical-Study-Measures

1.  Ralph Benedict concluded that of all volume measurements the one that correlated best with cognitive deficits was third ventricle enlar...

1.  CRION is rare in children is steroid dependent optic neuritis, relapse off steroids 2.  One presenter stated that ON + TM presentatio...

1.  PPMS is very rare before age 18 2. associations include lots EBV, early menarche, obesity, HLA DR1*15 3. Kids with MS look genetica...

SSD guide MS Society nationalMSsociety.org/SSDguide how to guide checklist of actions to take legal information *************** Pra...

Mary Harroun 21350 South Sylvan Drive Mendelein IL 60060 ph 847-837-9580 f     847-837-8582 www.merrywalker.com merrywalker@comcast...

Russo M, Guarneri C, Mazzon E, et al.  Mayo Clin Proc 2015; 90(10)1424-7   prurplish acral lesion reappeared with rechallenge four y...

The   University of California, San Francisco   (UCSF) initiated a clinical trial to evaluate the antihistamine clemastine fumarate,...

http://www.mypacemaker.com/mri-pacemakers/getting-a-pacemaker/index.htm?gclid=CjwKEAjwxMetBRDJx6Sz2p7DsQ0SJADJHAqNfosE_xSHoRpQbsztutw7...

  = Basically there newer models of pacemakers that are MRI conditional given less use of ferromagnetic materials and more sophistic...

   

Oh J, Saidha S, Cortese I, et al.  Daclizumab induced side effects in multiple organ systems in multiple sclerosis. Neurology 2014; 82: ...

editorial:  Bourdette D, Gilden D.  Neurology 2012; 79: 1942-3   This editorial goes with four case reports in same journal about ...

1.  Standard guidelines indicate use of a killed and not inactivated vaccine v. influenzae is safe, but it should not be given during a ...

Kim et al.  MRI characteristics of neuromyelitis optica spectrum disorder: an international update.Neurology 2015; 84: 1165-1173   W...

The only published data on indices that I am aware of, is in the Annals publication ("Anti–JC Virus Antibody Levels in Serum or Pla...

Magana SM, Keegan M, Weinshenker BG, et al.,Beneficial plasma exchange response in central nervous sytem inflammatory demyelination.  Ar...

Bowel incontinence in MS occurs in two principal situations…(1) an augmented gastrocolic reflex (colonic motility with gastric diste...

Lublin FD, Reingold SC, Cohen JA, et al.  Defining the clinical course of multiple sclerosis: the 2013 revisions.  Neurology 2014; 83:...

Herrera BM, Ramagopalan SV, Lincoln MR, et al.  Parent of origin effects in MS. Observations from avuncular pairs.  Neurology; 2008: 7...

Birnbaum G., Iverson J.  Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclerosis.  Neurology 2014; 83: ...

Annette M. Langer-Gould, Neurology 83; 2014:1685. response to a letter to editor. Teriflunamide is the active ingredient of leflunomid...

Cugati S. et al.  Neurology Clinical Practice, October, 2014 Review article Pearls 1. Mechanism is drug acts of S1P3 receptor as ago...

old paper, useful insights Menge T, Hemmer B, Nessler S et al  Acute disseminated encephalomyelitis: an update. Arch Neurol 2005; ...

Hedstrom AK, Hillert J, Olsson T et al.  Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk.  Jama Neurology 201...

Kitley J, Waters P, Woodhall M, et al. Neuromyelitis optica spectrum disorders with aquaphorin-4 and Myelin-oligodendrocyte glycoprotein...

Types of memory loss in ms Meta memory Cognitive fatigue Social emotional function   Mspt Rudick has iPad based testing ...

Tysabri Alopecia Dermatographia Bulbous pemphigoid Liver crisis Treatment withdrawal a Relapse on discontinuation Fingol...

Tysabri Alopecia Dermatographia Bulbous pemphigoid Liver crisis Treatment withdrawal a Relapse on discontinuation Fingol...

Miscellany Consortium 2014   MRI pearls   1)  T2 much better than flair in post fossa 2)  Black holes can resolve sometimes;...

Rolf et al.  Paroxysmal atrial fibrillation after initiation of fingolimod for multiple sclerosis treatment   42 year old male had P...

Karlsson G, Francis G, Koren G, et al. Pregnancy outcomes in the clinical development of fingolimod in multiple sclerosis.  Neurology 20...

Joanna Kitley , BM, BS * ,  Mark Woodhall , PhD * ,  Patrick Waters , PhD * ,  M. Isabel Leite , DPhil ,  Emma Devenney , MB, Bch, Ba...

1. 0.5 to 1 mg of glycopyrrolate (Robinul) for GI 2. Baby ASA + 10mg of Zyrtec for flush, hot, etc.  Above taken 30-60 minutes b...

review article  Chan A and LoCoCo F.  MTX related acute leukemia in MS. An open or closed book> Neurology 2013; 80"1529-33. Pea...

1.  70 % of MS patients have impaired sweating, or delayed sweating.  This complicates efforts to manage heat intolerance.   2. ...

Tan IL, McArthur JC, Clifford DB, et al.  Immune reconstitution syndrome (IRIS) in natalizumab associated PML.  Neurology 2011; 77: 1061-1...

Gold R et al. Define Investigators.  Placebo-controlled phase 3 study of oral BG12 for relapsing multiple sclerosis. NEJM 367:1098-1107 , 2...

Signals of progressive multifocal leukoencephalopathy for immunosuppressants: a disproportionality analysis of spontaneous reports wit...

La Mantia L, Vacchi L, Rovaris M et al.  JNNP 2012 Cochrane analysis of placebo controlled trials 1995-2012. 5 trials, 3082 patients. IFN...

Random Notes   1.  Tereflunomide- blocks de novo synthesis of pyrimidine synthesis   "Nobody has a clue how these things re...

These are random notes of interest   1  Natalizumab was originally used for MS relapses in the 1990s, published in Neurology; negati...

Jeffrey Cohen on Gilenya   1. O.5 mg daily is only approved dose, lower doses are being tested 2. May take a month or more to comple...