Contraindications of tizanidine (Zanaflex)

based on updated safety printout of Acorda Therapeutics. Beware of other CYP1A2 inhibitors that can cause toxicity. Beware of Ciprofloxacin, , fluvoxamine, other fluoroquinolones, antiarrythmics (amiodarone, mexiletine, propafenone, verapamil) cimetidine, famotidine, oral contraceptives, acyclovir, ticlodipine. The combinations can lead to potentiated sedative and hypotensive effects. tylenol used concomitantly delays t max by about twenty minutes.