See Neurology suppl. 3 2002 p. S29
Authors note that in the main clinical trials the correlations between relapse rate and EDSS progression with T2 burden are generallyin the range of 0.15 to 0.30. MRI cannot be used to predict EDSS progression or relapse rate. Autors cite the "Prentice criteria" a statistical look at what makes a surrogate marker. (Prentice R. Surrogate markers in clinicl trials: definition and operational criteria. Stat Med 1989; 8:431-440) states the surrogate marker must closely mirror the gold standard which here, is clinical activity.
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