PRECISE Comit et al CIS and copaxone 481 patients 81 centers 1:1 randomization 3 years then open label robust effect on conversion to CDMS, black holes, EDSS data is pending.
FORTE study-- dosage study of copaxone 20 v. 40 mg 1155 patients 12 months negative result
CHAMPS (older study ) best prediictor of relapse is Gd++ lesions
BEYOND-- Betaseron 25v. Betaseron50 v. copaxone-- year two brain atrophy data was -.63, -.64 and -.59 respectively, favoring copaxone
REGARD year two atrophy -.6% for rebif,-.5 % for copaxone favors copaxone but beware of pseudoatrophy effect in year one
CAREMS1 phase 3 Campath trial for naive early active patients
CAREMS2 phase 3 Campath trial for treatment failures on IFN who relapse with rrms 1200 patients
Freedoms fingolimid, 2 doses .5 and 1.25 v placebo
Tranforms fingolimid v avonex
DEFINE BG12 fumarate dose finding 240 bid v tid
CONFIRM fumarate v. comparator (which one?)
CLARITY cladribine phase 3 pivotal fast track
ORACLE cladribine trial for CIS
BRAVO laquinomodv. placebo for rrms
OlympusRituxan v.placebo for PPMS failed trial in press
HERMES Rituxan v. placebo for rrms reported in NEJM 2008
CAMMS223 Campath for RRMS phase 2 trial in press NEJM
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1 comment:
a compound that Serono just licensed to develop and market called ATX-MS-1467. Apparently, it is derived from MBP and is designed to induce tolerance of the body's t cells to autoantigens involved in MS. Very little info at this point....
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