Thursday, February 26, 2009
Early MRI in ON" Risk for disability
Swanton et al. Neurology 2009; 72: 542-550. (Queen's Square)
106/143 patients reached scheduled five year followup after being diagnosed with ON. 100 were evaluated clinically. At median 6 years, 48 % converted to CDMS 52 % did not. At baseline, the presence and number of spinal cord lesions and new T2 lesions at followup (odds ratio, respectively of 3.3, 1.94, 7.12) predicted higher disability. Also Gd+ lesions and number of infratentotial lesions at baseline were predictive.
Many factors were not predictive including age, gender, baseline EDSS, spectros/MTR measures, NOT baseline lesion number although lesion load at 5 years and increase from baseline was predictive.
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I forgot that I was subscribed to your blog.
I would be one of the 48% who converted to Definite MS just beyond 5 years (5.5 yrs). At the time of ON dx, MRIs were not conducted of my cervical spine so I can't compare any change there. But as I approached five years, I thought that I might have had it in the clear. Oh well.
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