1. Standard guidelines indicate use of a killed and not inactivated vaccine v. influenzae is safe, but it should not be given during a relapse.
2. Response to vaccines is high in standard therapies, but two new oral vaccines have a slightly lower response: teriflunomide in the 14 mg dose is effective in only 76 % of one particular strain (v.about 90 %)
3. Fingolimod was effective in only 54 % with weakness v. certain strains such as California strain. However the incidence of influenza was comparable in patients and controls in this 2015 study published in Neurology.