1. PPMS is very rare before age 18
2. associations include lots EBV, early menarche, obesity, HLA DR1*15
3. Kids with MS look genetically like adults with MS
4. Kids can have lesion disappearance between attacks that can be confusing
5. Teens have lots of cortical lesions, atrophy, that corresponds with IQ
6. ADEM kids also have atrophy especially thalamus
7. Need to be 11 to accurately use McDonald criteria
8. Incidence is 1:100,000
9. Consider differential diagnosis in kids including ADEM,NMO, MOG, CRION (see separate post). Well trained radiologists can be very helpful. In a series of 110 kids with demyelinating disease, 56 had MS, 25 had NMOSD, 12 had ADEM and 5 had RION
10. RR is 2-3 times higher and disability rate is higher
11. Don't diagnose with a presentation of encephalopathy
source- lectures at Consortium meeting session on pediatric MS 2017
2. associations include lots EBV, early menarche, obesity, HLA DR1*15
3. Kids with MS look genetically like adults with MS
4. Kids can have lesion disappearance between attacks that can be confusing
5. Teens have lots of cortical lesions, atrophy, that corresponds with IQ
6. ADEM kids also have atrophy especially thalamus
7. Need to be 11 to accurately use McDonald criteria
8. Incidence is 1:100,000
9. Consider differential diagnosis in kids including ADEM,NMO, MOG, CRION (see separate post). Well trained radiologists can be very helpful. In a series of 110 kids with demyelinating disease, 56 had MS, 25 had NMOSD, 12 had ADEM and 5 had RION
10. RR is 2-3 times higher and disability rate is higher
11. Don't diagnose with a presentation of encephalopathy
source- lectures at Consortium meeting session on pediatric MS 2017
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